Endocrine Abstracts

68 year old lady was on amiodarone for atrial fibrillation and poor left ventricular systolic function. She was feeling unwell, so she had some blood tests which showed elevated free T4 and suppressed TSH. She did not have a family history of thyroid disease. She did not have a goitre or eye signs. She did not have overt signs of thyrotoxicosis. She was admitted as her heart failure was not controlled and her diuretics were optimised. Her thyroid antibodieswere checked and was...

Mrs XY, 29 years. (gravida: 3 and para 2) was admitted under the obstetricians with severe hyperemesis gravidarum (HG). An ultrasonogram revealed single live foetus of 8 weeks gestation. Her two previous pregnancies were normal with no history of HG. Mrs XY was on levothyroxine 150 μg OD for autoimmune primary hypothyroidism with TPO antibodies of 259 kU/l (0–5.6). She was also taking sertraline 200 mg OD for depression. The hyperemesis settled with i.v. fluids as we...

Mrs XY, 28 years. primigravida was seen for PV bleed. Ultrasonogram confirmed live intrauterine foetus of 8 weeks gestation with no obvious cause for PV bleeding. An OGTT at 21 weeks suggested gestational diabetes. She was referred to Diabetes Nurse led clinic and treated with metformin. Hypertension was recorded and controlled with labetalol and amlodipine. Mrs XY had recurrent admissions for PV bleeds and some polycythaemia. She was seen by the haematologist and a diagnosis ...

Case: A 35-year-old man was referred by the haematologists. He had been previously diagnosed with dilated cardiomyopathy and later underwent a cardiac transplant. Following this, he suffered an anterior wall myocardial infarction with subsequent congestive cardiac failure. A coronary angiogram did not reveal any evidence of allograft coronary artery disease. His medications included diuretics, immunosuppressants and warfarin. There was no significant family history. Clinical e...

A 52-years man was admitted following a Road Traffic Accident.He was a known smoker but usually fit and well. During the road traffic accident he sustained fracture of all four limbs, clavicles, facial bones as well as multiple rib fractures.Following initial stabilisation in ITU he underwent multiple orthopaedic surgeries for his bony fractures over the next 2–3 months.He was then noticed to have elevat...

A 48-year man, referred with symptoms suggestive of phaeochromocytoma and elevated 24 h urinary noradrenalin level. He had a background history of obstructive sleep apnoea, controlled hypertension and obesity. His medications included Amlodipine 10 mg od, Modafinil 200 mg daily, Amitriptyline 10 mg and Rabeprazole.Obstructive sleep apnoea was diagnosed at 39 years. CPAP was tried and later Modafinil 100 mg daily. A few months prior to referral his Modafi...

Summary: A case of intermittent hypercalcemia with a suppressed parathyroid hormone (PTH) for nearly 3 years. It was found that high calcium specifically occurred in summer and each one lasted for about a month. Once calcium normalised the renal function also improved. Exact aetiology has not been found even after extensive investigations.Case presentation: A 67-year-old gentleman first presented to the endocrine clinic in early 2014 with Hypercalcemia. ...

Adrenocortical carcinoma are rare, highly vascular tumours with a generally poor prognosis. We have studied the use of the antiangiogenic drug, thalidomide (TH), in 6 patients with metastatic adrenocortical carcinoma (5 patients had adrenalectomy and one patient was inoperable#). The response to thalidomide treatment is summarized in the following Table. Assuming the residual/metastatic tumours to have a spheroidal form, the tumour volume (V) was calculated using the eq...